South Park is totally alive and well and still frequently uses the 'Oh my God, they killed Kenny!' statement enough. People will get it. Even more than Pokémon. More like The Simpsons.
I think Buffy, Xena, and such quotes are fairly safe too, though getting an occasional House, Bones, or Grey's Anatomy quote doesn't seem out of the question. Which I mean, I love those shows, so sounds fair enough to me.
But as long as my favorite quotes are all in there, I'm good. Of course, they have to get to re-printing the whole series for most of my favorite quotes to even be touched.